Syria’s rebels launched a bold attack in Damascus Wednesday, unleashing a  bomb during a high-level security meeting that killed three top officials in the  regime, including President Bashar Assad’s brother-in-law.

State-run TV said the blast came during a Cabinet meeting of senior officials  in Damascus, which has seen four straight days of bloodshed.

The killings could signal a change in the civil war, a turning point that has  seen the violence escalate and grow more chaotic.

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Guest Alert: 12:35 Wed. Congressman Ed Royce on Syria's WMD's